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dc.contributor.authorEngeseth, Merete Salveson
dc.contributor.authorEngan, Mette
dc.contributor.authorClemm, Hege Synnøve Havstad
dc.contributor.authorVollsæter, Maria
dc.contributor.authorNilsen, Roy Miodini
dc.contributor.authorMarkestad, Trond Jacob
dc.contributor.authorHalvorsen, Thomas
dc.contributor.authorRøksund, Ola Drange
dc.identifier.citationEngeseth, M. S., Engan, M., Clemm, H., Vollsæter, M., Nilsen, R. M., Markestad, T., . . . Røksund, O. D. (2020). Voice and exercise related respiratory symptoms in extremely preterm born children after neonatal patent ductus arteriosus. Frontiers in Pediatrics, 8en_US
dc.description.abstractObjective: To investigate voice characteristics and exercise related respiratory symptoms in extremely preterm born 11-year-old children, focusing particularly on associations with management of a patent ductus arteriosus (PDA). Study design: Prospective follow-up of all children born in Norway during 1999–2000 at gestational age <28 weeks or with birthweight <1,000 g. Neonatal data were obtained prospectively on custom-made registration forms completed by neonatologists. Voice characteristics and exercise related respiratory symptoms were obtained at 11 years by parental questionnaires. Result: Questionnaires were returned for 228/372 (61%) eligible children, of whom 137 had no history of PDA. PDA had been noted in 91 participants, of whom 36 had been treated conservatively, 21 with indomethacin, and 34 with surgery. Compared to the children treated with indomethacin or conservatively, the odds ratio (95% confidence interval) for the surgically treated children were 3.4 (1.3; 9.2) for having breathing problems during exercise, 16.9 (2.0; 143.0) for having a hoarse voice, 4.7 (1.3; 16.7) for a voice that breaks when shouting, 4.6 (1.1; 19.1) for a voice that disturbs singing, and 3.7 (1.1; 12.3) for problems shouting or speaking loudly. The significance of surgery per se was uncertain since the duration of mechanical ventilation was associated with the same outcomes. Conclusion: Extremely preterm born children with a neonatal history of PDA surgery had more problems with voice and breathing during exercise in mid-childhood than those whose PDA had been handled otherwise. The study underlines the causal heterogeneity of exercise related respiratory symptoms in preterm born children.en_US
dc.publisherFrontiers Media S.A.en_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.subjectpatent ductus arteriosusen_US
dc.subjectextremely premature infanten_US
dc.subjectextremely low birth weight infanten_US
dc.subjectvoice qualityen_US
dc.subjectrespiratory symptomsen_US
dc.subjectcohort studyen_US
dc.titleVoice and Exercise Related Respiratory Symptoms in Extremely Preterm Born Children After Neonatal Patent Ductus Arteriosusen_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.rights.holderCopyright © 2020 Engeseth, Engan, Clemm, Vollsæter, Nilsen, Markestad, Halvorsen and Røksund.en_US
dc.source.journalFrontiers in pediatricsen_US

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Navngivelse 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Navngivelse 4.0 Internasjonal