Vis enkel innførsel

dc.contributor.authorGejl, Anne Kær
dc.contributor.authorEnevold, Christian
dc.contributor.authorBugge, Anna
dc.contributor.authorAndersen, Marianne Skovsager
dc.contributor.authorNielsen, Claus Henrik
dc.contributor.authorAndersen, Lars Bo
dc.date.accessioned2019-12-10T10:08:33Z
dc.date.available2019-12-10T10:08:33Z
dc.date.created2019-08-23T11:41:38Z
dc.date.issued2019
dc.identifier.citationGejl, A. K., Enevold, C., Bugge, A., Andersen, M. S., Nielsen, C. H., & Andersen, L. B. (2019). Associations between serum and plasma brain-derived neurotrophic factor and influence of storage time and centrifugation strategy. Scientific Reports, 9(1).nb_NO
dc.identifier.issn2045-2322
dc.identifier.urihttp://hdl.handle.net/11250/2632434
dc.description.abstractThe aims of the study were to clarify the impact of storage time and centrifugation strategy on brain-derived neurotrophic factor (BDNF) levels in human serum and plasma samples. In addition, we analyzed associations between BDNF levels, cardiorespiratory ftness and waist circumference. Seventeen healthy males (25.2 (4.1) years) were included in the study. Blood samples were drawn after an overnight fast and treated to diferent protocols, varying in time before centrifugation and centrifugation strategy. BDNF was analyzed in serum, normal plasma (NP) and platelet-poor plasma (PPP). Also, waist circumference and cardiorespiratory ftness were measured. A large increase was observed in serum BDNF levels during the frst hour of clotting. BDNF in NP correlated with PPP, whereas no correlations were found between BDNF in serum and plasma. Though not statistical signifcant, correlations between ftness and BDNF in serum changed from positive at 30min. to negative when clotting time was ≥60min. In conclusion, BDNF levels in serum were afected by clotting time, whereas BDNF levels in plasma were infuenced by centrifugation strategy. Importantly, BDNF in serum and plasma appears to refect two diferent pools of BDNF. The biological relevance of the velocity of BDNF release during clotting and its dependence upon ftness must be investigated further.nb_NO
dc.language.isoengnb_NO
dc.publisherNature Publishing Groupnb_NO
dc.rightsNavngivelse 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.no*
dc.titleAssociations between serum and plasma brain-derived neurotrophic factor and influence of storage time and centrifugation strategynb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.description.versionpublishedVersionnb_NO
dc.rights.holder© The Author(s) 2019nb_NO
dc.source.pagenumber9nb_NO
dc.source.volume9nb_NO
dc.source.journalScientific Reportsnb_NO
dc.identifier.doi10.1038/s41598-019-45976-5
dc.identifier.cristin1718247
dc.relation.projectSDU2020: 15713nb_NO
dc.relation.projectTrygfonden: 104982nb_NO
cristin.unitcode203,10,1,0
cristin.unitnameInstitutt for idrett, kosthald og naturfag
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1


Tilhørende fil(er)

Thumbnail

Denne innførselen finnes i følgende samling(er)

Vis enkel innførsel

Navngivelse 4.0 Internasjonal
Med mindre annet er angitt, så er denne innførselen lisensiert som Navngivelse 4.0 Internasjonal