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dc.contributor.authorYtre-Hauge, Kristian
dc.contributor.authorSkjerdal, Kyrre
dc.contributor.authorMattingly, John
dc.contributor.authorMeric, Ilker
dc.date.accessioned2019-06-04T08:25:19Z
dc.date.available2019-06-04T08:25:19Z
dc.date.created2019-04-25T18:37:36Z
dc.date.issued2019
dc.identifier.citationYtre-Hauge, K. S., Skjerdal, K., Mattingly, J. & Meric, I. (2019). A Monte Carlo feasibility study for neutron based real-time range verification in proton therapy. Scientific Reports, 9(1).nb_NO
dc.identifier.issn2045-2322
dc.identifier.urihttp://hdl.handle.net/11250/2599839
dc.description.abstractUncertainties in the proton range in tissue during proton therapy limit the precision in treatment delivery. These uncertainties result in expanded treatment margins, thereby increasing radiation dose to healthy tissue. Real-time range verification techniques aim to reduce these uncertainties in order to take full advantage of the finite range of the primary protons. In this paper, we propose a novel concept for real-time range verification based on detection of secondary neutrons produced in nuclear interactions during proton therapy. The proposed detector concept is simple; consisting of a hydrogen-rich converter material followed by two charged particle tracking detectors, mimicking a proton recoil telescopic arrangement. Neutrons incident on the converter material are converted into protons through elastic and inelastic (n,p) interactions. The protons are subsequently detected in the tracking detectors. The information on the direction and position of these protons is then utilized in a new reconstruction algorithm to estimate the depth distribution of neutron production by the proton beam, which in turn is correlated with the primary proton range. In this paper, we present the results of a Monte Carlo feasibility study and show that the proposed concept could be used for real-time range verification with millimetric precision in proton therapy.nb_NO
dc.language.isoengnb_NO
dc.publisherNature Publishing Groupnb_NO
dc.rightsNavngivelse 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.no*
dc.titleA Monte Carlo feasibility study for neutron based real-time range verification in proton therapynb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.description.versionpublishedVersionnb_NO
dc.rights.holder© The Author(s) 2019nb_NO
dc.subject.nsiVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Onkologi: 762nb_NO
dc.source.pagenumber1-9nb_NO
dc.source.volume9nb_NO
dc.source.journalScientific Reportsnb_NO
dc.source.issue2011nb_NO
dc.identifier.doi10.1038/s41598-019-38611-w
dc.identifier.cristin1693997
cristin.unitcode203,12,4,0
cristin.unitcode203,12,5,0
cristin.unitnameInstitutt for data- og realfag
cristin.unitnameInstitutt for elektrofag
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1


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