dc.contributor.author | Pedersen, Natascha Holbæk | |
dc.contributor.author | Tarp, Jakob | |
dc.contributor.author | Andersen, Lars Bo | |
dc.contributor.author | Gejl, Anne Kær | |
dc.contributor.author | Huang, Tao | |
dc.contributor.author | Peijs, Lone | |
dc.contributor.author | Bugge, Anna | |
dc.date.accessioned | 2019-05-23T09:02:21Z | |
dc.date.available | 2019-05-23T09:02:21Z | |
dc.date.created | 2017-11-24T12:08:26Z | |
dc.date.issued | 2017 | |
dc.identifier.citation | Hashimoto, K., Pedersen, N. H., Tarp, J., Andersen, L. B., Gejl, A. K., Huang, T., . . . Bugge, A. (2017). The association between serum brain-derived neurotrophic factor and a cluster of cardiovascular risk factors in adolescents: The CHAMPS-study DK. Plos One, 12(10):e0186384 | nb_NO |
dc.identifier.issn | 1932-6203 | |
dc.identifier.uri | http://hdl.handle.net/11250/2598535 | |
dc.description.abstract | Background and objective
Cardiovascular disease and type 2 diabetes pose a global health burden. Therefore, clarifying the pathology of these risk factors is essential. Previous studies have found positive and negative associations between one or more cardiovascular risk factors and brain-derived neurotrophic factor (BDNF) probably due to diverse methodological approaches when analysing peripheral BDNF levels. Moreover, only a few studies have been performed in youth populations. Consequently, the main objective of this study was to examine the association between serum BDNF and a composite z-score consisting of six cardiovascular risk factors. A secondary aim was to examine the associations between serum BDNF and each of the six risk factors.
Methods
Four hundred and forty-seven apparently healthy adolescents between 11–17 years of age participated in this cross-sectional study. Cardiorespiratory fitness (CRF), anthropometrics, pubertal status, blood pressure (BP), serum BDNF, high-density lipoprotein cholesterol (HDL-C), triglyceride (TG), blood glucose and insulin were measured. Information about alcohol consumption and socio-economic status was collected via questionnaires. Associations were modelled using linear regression analysis.
Results
Serum BDNF was positively associated with the composite z-score in the total study sample (standardized beta coefficient (std.β) = 0.10, P = 0.037). In males, serum BDNF was positively associated with the composite z-score (Std. β = 0.14, P = 0.034) and HOMA-IR (Std. β = 0.19, P = 0.004), and negatively associated with CRF (Std. β = -0.15, P = 0.026). In females, BDNF was positively associated with TG (Std. β = 0.14, P = 0.030) and negatively associated with waist circumference (WC) (Std. β = -0.16, P = 0.012).
Conclusion
Serum BDNF was positively associated with a composite z-score of cardiovascular risk factors. This association seems to be mainly driven by the association between TG, HOMA-IR and serum BDNF, and particularly for males. Further longitudinal research is warranted to determine the temporal relationship between BDNF and cardiovascular risk factors. | nb_NO |
dc.language.iso | eng | nb_NO |
dc.publisher | Public Library of Science | nb_NO |
dc.rights | Navngivelse 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/deed.no | * |
dc.title | The association between serum brain-derived neurotrophic factor and a cluster of cardiovascular risk factors in adolescents: The CHAMPS-study DK | nb_NO |
dc.type | Journal article | nb_NO |
dc.type | Peer reviewed | nb_NO |
dc.description.version | publishedVersion | nb_NO |
dc.rights.holder | © 2017 Pedersen et al. | nb_NO |
dc.subject.nsi | VDP::Medisinske Fag: 700::Idrettsmedisinske fag: 850 | nb_NO |
dc.subject.nsi | VDP::Medisinske Fag: 700::Helsefag: 800 | nb_NO |
dc.source.pagenumber | 1-12 | nb_NO |
dc.source.volume | 12:e0186384 | nb_NO |
dc.source.journal | PLoS ONE | nb_NO |
dc.source.issue | 10 | nb_NO |
dc.identifier.doi | 10.1371/journal.pone.0186384 | |
dc.identifier.cristin | 1518098 | |
cristin.unitcode | 203,5,2,0 | |
cristin.unitname | Avdeling for lærarutdanning og idrett - Sogn og Fjordane | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |