dc.contributor.author | Christensen, Monika | |
dc.contributor.author | Fadnes, Dag Jone Stokke | |
dc.contributor.author | Røst, Therese Halvorsen | |
dc.contributor.author | Pedersen, Eva Ringdal | |
dc.contributor.author | Andersen, John Roger | |
dc.contributor.author | Våge, Villy | |
dc.contributor.author | Ulvik, Arve | |
dc.contributor.author | Midttun, Øivind | |
dc.contributor.author | Ueland, Per Magne | |
dc.contributor.author | Nygård, Ottar | |
dc.contributor.author | Mellgren, Gunnar | |
dc.coverage.spatial | Norway, Sogn og Fjordane | nb_NO |
dc.date.accessioned | 2019-01-23T13:03:01Z | |
dc.date.available | 2019-01-23T13:03:01Z | |
dc.date.created | 2018-06-05T12:17:55Z | |
dc.date.issued | 2018 | |
dc.identifier.citation | Pietropaolo, M., Christensen, M. H. E., Fadnes, D. J., Røst, T. H., Pedersen, E. R., Andersen, J. R., . . . Mellgren, G. (2018). Inflammatory markers, the tryptophan-kynurenine pathway, and vitamin B status after bariatric surgery. Plos One, 13(2), 1-14. | nb_NO |
dc.identifier.issn | 1932-6203 | |
dc.identifier.uri | http://hdl.handle.net/11250/2581944 | |
dc.description.abstract | Objective
Obesity is associated with increased inflammation and insulin resistance. In conditions with chronic immune activation, low plasma vitamin B6-levels are described, as well as an increased kynurenine:tryptophan-ratio (KTR). We investigated circulating tryptophan, kynurenine and its metabolites, neopterin, B-vitamins, CRP, and HbA1c in individuals with obesity before and after bariatric surgery.
Methods
This longitudinal study included 37 patients with severe obesity, scheduled for bariatric surgery. Blood samples were taken at inclusion and at three months and one year postoperatively.
Results
We observed significant positive correlations between HbA1c and both 3-hydroxy-kynurenine and 3-hydroxyanthranilic acid at inclusion. After surgery, fasting glucose, HbA1C and triglycerides decreased, whereas HDL-cholesterol increased. Tryptophan, kynurenine and its metabolites, except for anthranilic acid, decreased during weight loss. The KTR and CRP decreased while vitamin B6 increased during the year following operation, indicating reduced inflammation (all p<0.05).
Conclusions
In patients with obesity subjected to bariatric surgery, levels of 3-hydroxykynurenine and 3-hydroxyanthranilic acid seemed to be positively correlated to impaired glucose tolerance. One year following surgery, plasma levels of the kynurenine metabolites were substantially decreased, along with a metabolic improvement. The relation of circulating kynurenine pathway metabolites with biomarkers of metabolic impairment in patients with obesity needs further evaluation | nb_NO |
dc.language.iso | eng | nb_NO |
dc.publisher | PLoS | nb_NO |
dc.rights | Navngivelse 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/deed.no | * |
dc.title | Inflammatory markers, the tryptophan-kynurenine pathway, and Vitamin B status after bariatric surgery | nb_NO |
dc.type | Journal article | nb_NO |
dc.type | Peer reviewed | nb_NO |
dc.description.version | publishedVersion | nb_NO |
dc.rights.holder | © 2018 Christensen et al. | nb_NO |
dc.subject.nsi | VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750 | nb_NO |
dc.source.pagenumber | 1-14 | nb_NO |
dc.source.volume | 13 | nb_NO |
dc.source.journal | PLoS ONE | nb_NO |
dc.source.issue | 2 | nb_NO |
dc.identifier.doi | 10.1371/journal.pone.0192169 | |
dc.identifier.cristin | 1589038 | |
cristin.unitcode | 203,5,1,0 | |
cristin.unitname | Avdeling for helsefag - Sogn og Fjordane | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |