dc.contributor.author | Bjørneklett, Rune | |
dc.contributor.author | Bostad, Leif | |
dc.contributor.author | Fismen, Anne-Siri | |
dc.coverage.spatial | Norway | nb_NO |
dc.date.accessioned | 2019-01-22T14:18:12Z | |
dc.date.available | 2019-01-22T14:18:12Z | |
dc.date.created | 2018-07-13T13:10:07Z | |
dc.date.issued | 2018 | |
dc.identifier.citation | Bjørneklett, R., Bostad, L., & Fismen, A.-S. (2018). Prognosis and histological classification in elderly patients with anca-glomerulonephritis: A registry-based cohort study. BioMed Research International, 2018, 1-8. | nb_NO |
dc.identifier.issn | 2314-6133 | |
dc.identifier.uri | http://hdl.handle.net/11250/2581825 | |
dc.description.abstract | Background. The value of a histologic classification scheme to classify patients with anti-neutrophil cytoplasmic antibody-associated glomerulonephritis (ANCA-GN) into focal, mixed, crescentic, and sclerotic types for predicting risk of end-stage renal disease (ESRD) is well documented. However, the prognostic value of histological classification specifically in elderly patients (≥70 years) with ANCA-GN has not previously been investigated. Methods. Patients with biopsy-verified pauci-immune necrotizing glomerulonephritis were identified from the Norwegian Kidney Biopsy Registry between 1991 and 2012 and those ≥70 years of age at the time of diagnosis and having positive anti-neutrophil cytoplasmic antibody serology were included in this study. The incidence rate of ESRD and/or death was determined by linking the study cohort to the Norwegian Renal Registry and the Population Registry of Norway. The ESRD-free survival and patient survival were compared between the 4 histological types. Results. Of the 81 patients included, 20 progressed to ESRD and 34 died. The 1-year and 5-year ESRD-free survival varied between histological groups ( = 0.003) as follows: focal, 97% and 97%, respectively; mixed, 70% and 57%; crescentic, 76% and 63%; and sclerotic, 49% and 49%. Patient survival did not differ significantly between groups ( = 0.30). Conclusion. Histological classification in elderly patients with ANCA-GN is useful for predicting ESRD but not survival. | nb_NO |
dc.language.iso | eng | nb_NO |
dc.publisher | Hindawi | nb_NO |
dc.rights | Navngivelse 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/deed.no | * |
dc.title | Prognosis and Histological Classification in Elderly Patients with ANCA-Glomerulonephritis: A Registry-Based Cohort Study | nb_NO |
dc.type | Journal article | nb_NO |
dc.type | Peer reviewed | nb_NO |
dc.description.version | publishedVersion | nb_NO |
dc.rights.holder | Copyright © 2018 Rune Bjørneklett et al. | nb_NO |
dc.subject.nsi | VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Nefrologi, urologi: 772 | nb_NO |
dc.source.volume | 2018 | nb_NO |
dc.source.journal | BioMed Research International | nb_NO |
dc.identifier.doi | 10.1155/2018/7581567 | |
dc.identifier.cristin | 1597129 | |
cristin.unitcode | 203,0,0,0 | |
cristin.unitname | Høgskulen på Vestlandet | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |