dc.contributor.author | Solbakken, Vilde | |
dc.contributor.author | Fismen, Anne-Siri | |
dc.contributor.author | Bostad, Leif | |
dc.contributor.author | Bjørneklett, Rune | |
dc.coverage.spatial | Norway | nb_NO |
dc.date.accessioned | 2019-01-16T08:47:39Z | |
dc.date.available | 2019-01-16T08:47:39Z | |
dc.date.created | 2018-10-22T11:59:04Z | |
dc.date.issued | 2018 | |
dc.identifier.citation | Solbakken, V., Fismen, A.-S., Bostad, L., & Bjørneklett, R. (2018). Impact of Proteinase 3 versus Myeloperoxidase Positivity on Risk of End-Stage Renal Disease in ANCA-Associated Glomerulonephritis Stratified by Histological Classification: A Population-Based Cohort Study. Disease Markers, 2018, 1-7. | nb_NO |
dc.identifier.issn | 0278-0240 | |
dc.identifier.uri | http://hdl.handle.net/11250/2580798 | |
dc.description.abstract | Background. End-stage renal disease (ESRD) risk in patients with antineutrophil cytoplasmic antibody- (ANCA-) associated glomerulonephritis (ANCA-GN) according to ANCA serotype and stratified by histological classification has not been previously investigated. Methods. Patients from the Norwegian Kidney Biopsy Registry (NKBR) between 1991 and 2012 who had biopsy-verified pauci-immune glomerulonephritis and positive antineutrophil cytoplasmic antibody serology were included. Cases with ESRD during follow-up were identified in the Norwegian Renal Registry. ESRD-free survival with proteinase 3 (PR3) versus myeloperoxidase- (MPO-) ANCA positivity stratified into 4 histological classes was investigated. Results. Three hundred fifty-eight patients, of whom 87 progressed to ESRD during follow-up, were included. Patients with PR3- as compared to MPO-ANCA were younger (58 versus 64 years, ), had a higher percentage of males (62 versus 41%, ), had a lower percentage with a sclerozing glomerulonephritis pattern (4 versus 16%, ), and had a significantly higher cumulative ESRD-free survival (90 versus 80%, ) at 1-year follow-up. No significant differences in cumulative ESRD-free survival with PR3- as compared to MPO-ANCA were observed by histological stratification. Conclusion. Advanced glomerular sclerosis is found more frequently in patients with MPO-ANCA, explaining the higher risk of ESRD. ANCA serotypes have no impact on prognosis of patients with similar histological findings. | nb_NO |
dc.language.iso | eng | nb_NO |
dc.publisher | Hindawi | nb_NO |
dc.rights | Navngivelse 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/deed.no | * |
dc.title | Impact of proteinase 3 versus myeloperoxidase positivity on risk of end-stage renal disease in ANCA-associated glomerulonephritis stratified by histological classification: A population-based cohort study | nb_NO |
dc.type | Journal article | nb_NO |
dc.type | Peer reviewed | nb_NO |
dc.description.version | publishedVersion | nb_NO |
dc.rights.holder | © 2018 Vilde Solbakken et al. | nb_NO |
dc.subject.nsi | VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Nefrologi, urologi: 772 | nb_NO |
dc.source.pagenumber | 1-7 | nb_NO |
dc.source.volume | 2018 | nb_NO |
dc.source.journal | Disease Markers | nb_NO |
dc.identifier.doi | 10.1155/2018/3251517 | |
dc.identifier.cristin | 1622213 | |
cristin.unitcode | 203,3,50,0 | |
cristin.unitname | Institutt for sykepleiefag - Bergen | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |