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dc.contributor.authorOnyango, Therese Bredholt
dc.contributor.authorZhou, Fan
dc.contributor.authorBredholt, Geir
dc.contributor.authorBrokstad, Karl Albert
dc.contributor.authorJalloh, Sarah Larteley Lartey
dc.contributor.authorMohn, Kristin Greve-Isdahl
dc.contributor.authorÖzgümüs, Türküler
dc.contributor.authorKittang, Bård Reiakvam
dc.contributor.authorLinchausen, Dagrun Waag
dc.contributor.authorShafiani, Shahin
dc.contributor.authorElyanow, Rebecca
dc.contributor.authorBlomberg, Bjørn
dc.contributor.authorLangeland, Nina
dc.contributor.authorCox, Rebecca Jane
dc.identifier.citationFrontiers in Immunology. 2023, 14 .en_US
dc.description.abstractObesity is a known risk factor for severe respiratory tract infections. In this prospective study, we assessed the impact of being obese or overweight on longitudinal SARS-CoV-2 humoral and cellular responses up to 18 months after infection. 274 patients provided blood samples at regular time intervals up to 18 months including obese (BMI ≥30, n=32), overweight (BMI 25-29.9, n=103) and normal body weight (BMI 18.5-24.9, n=134) SARS-CoV-2 patients. We determined SARS-CoV-2 spike-specific IgG, IgA, IgM levels by ELISA and neutralising antibody titres by neutralisation assay. RBD- and spike-specific memory B cells were investigated by ELISpot, spike- and non-spike-specific IFN-γ, IL-2 and IFN-γ/IL-2 secreting T cells by FluoroSpot and T cell receptor (TCR) sequencing was performed. Higher BMI correlated with increased COVID-19 severity. Humoral and cellular responses were stronger in overweight and obese patients than normal weight patients and associated with higher spike-specific IgG binding titres relative to neutralising antibody titres. Linear regression models demonstrated that BMI, age and COVID-19 severity correlated independently with higher SARS-CoV-2 immune responses. We found an increased proportion of unique SARS-CoV-2 specific T cell clonotypes after infection in overweight and obese patients. COVID-19 vaccination boosted humoral and cellular responses irrespective of BMI, although stronger immune boosting was observed in normal weight patients. Overall, our results highlight more severe disease and an over-reactivity of the immune system in overweight and obese patients after SARS-CoV-2 infection, underscoring the importance of recognizing overweight/obese individuals as a risk group for prioritisation for COVID-19 vaccination.en_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.titleSARS-CoV-2 specific immune responses in overweight and obese COVID-19 patientsen_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.rights.holder© 2023 Onyango, Zhou, Bredholt, Brokstad, Lartey, Mohn, Özgümüs, Kittang, Linchausen, Shafiani, Elyanow, Blomberg, Langeland, Cox and Bergen COVID-19 Research Groupen_US
dc.source.journalFrontiers in Immunologyen_US

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Navngivelse 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Navngivelse 4.0 Internasjonal