A rapid antibody screening haemagglutination test for predicting immunity to SARS-CoV-2 variants of concern
Ertesvåg, Nina Urke; Xiao, Julie; Zhou, Fan; Ljostveit, Sonja; Sandnes, Helene Heitmann; Lartey, Sarah; Sævik, Marianne; Hansen, Lena; Madsen, Anders; Mohn, Kristin Greve-Isdahl; Fjelltveit, Elisabeth Berg; Olofsson, Jan Stefan; Tan, Tiong Kit; Rijal, Pramilia; Schimanski, Lisa; Øyen, Siri; Brokstad, Karl Albert; Dunachie, Susanna; Jämsén, Anni; James, William S.; Harding, Adam C.; Harvala, Heli; Nguyen, Dung; Roberts, David; Patel, Monika; Gopal, Robin; Zambon, Maria; Wei, Leiyan; Gilbert-Jaramillo, Javier; Knight, Michael L.; Vaughan-Jackson, Alun; Dupont, Maeva; Lamikanra, Abigail A.; Klennerman, Paul; Townsend, Alain; Tøndel, Camilla; Kuwelker, Kanika; Blomberg, Bjørn; Bredholt, Geir; Onyango, Therese Bredholt; Vahokoski, Juha; Bansal, Amit; Trieu, Mai Chi; Amdam, Håkon; Akselsen, Per Espen; Skorge, Trude Duelien; Okkenhaug, Liv Heiberg; Linchausen, Dagrun Waag; Langeland, Nina; Cox Brokstad, Rebecca Jane
Peer reviewed, Journal article
Published version
Permanent lenke
https://hdl.handle.net/11250/3059014Utgivelsesdato
2022Metadata
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Sammendrag
The aim of this study was to rapidly investigate the immune responses after SARS-CoV-2 infection and vaccination of younger adults and the elderly. Antibodies are proteins produced by the immune system that are released into the bloodstream and help fight infections. A simple method using red blood cells obtained from blood was developed and used to detect antibodies to SARS-CoV-2. This test was able to measure protective antibodies to several variants of concern. The elderly had lower antibody responses after vaccination. Two vaccinations induced a broader antibody response to viral variants, similar to the response induced following Covid-19. This antibody detection method could be used as a finger prick test to rapidly detect specific antibodies to emerging variants and enable quick identification of individuals who might benefit from a booster vaccination.