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dc.contributor.authorMatsha, Tandi E
dc.contributor.authorRaghubeer, Shanel
dc.contributor.authorTshivhase, Abegail M
dc.contributor.authorDavids, Saarah FG
dc.contributor.authorHon, Gloudina M
dc.contributor.authorBjørkhaug, Lise
dc.contributor.authorErasmus, Rajiv T
dc.identifier.citationMatsha, T. E., Raghubeer, S., Tshivhase, A. M., Davids, S. F. G., Hon, G. M., Bjørkhaug, L., & Erasmus, R. T. (2020). Incidence of HNF1A and GCK MODY Variants in a South African Population. The Application of Clinical Genetics, Volume 13, 209-219.en_US
dc.description.abstractBackground and Aim: Maturity-onset diabetes of the young (MODY) is the result of single gene variants. To date, fourteen different MODY subtypes have been described. Variants in genes coding for glucokinase (GCK, MODY2) and hepatic nuclear factor 1 alpha (HNF1A, MODY3) are most frequently encountered. MODY patients are often misdiagnosed with type 1 or type 2 diabetes, resulting in incorrect treatment protocols. At the time of reporting, no data are available on MODY prevalence in populations from Africa. Our study aimed to investigate and report on the incidence of MODY-related variants, specifically HNF1A variants, in a population from the Western Cape. Methods: Study participants were recruited (1643 in total, 407 males, 1236 females) and underwent anthropometric tests. Thereafter, blood was collected, and real-time PCR was used to screen for specific variants in HNF1A and GCK genes. Results: Ninety-seven individuals (5.9%) were identified with a specific HNF1A gene polymorphism (rs1169288) and twelve (0.9%) with a GCK polymorphism (rs4607517). Conclusion: In total, 6.6% of the study population expressed MODY variants. To our knowledge, we are the first to report on MODY incidence in Africa. This research provides the basis for MODY incidence studies in South Africa, as well as data on non-Caucasian populations.en_US
dc.publisherDove Medical Pressen_US
dc.rightsNavngivelse-Ikkekommersiell 4.0 Internasjonal*
dc.titleIncidence of HNF1A and GCK MODY Variants in a South African Populationen_US
dc.typeJournal articleen_US
dc.typePeer revieweden_US
dc.rights.holder© 2020 Matsha et al.en_US
dc.source.journalThe Application of Clinical Geneticsen_US

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Navngivelse-Ikkekommersiell 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Navngivelse-Ikkekommersiell 4.0 Internasjonal