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dc.contributor.authorJohannessen, Ane
dc.contributor.authorLønnebotn, Marianne
dc.contributor.authorCalciano, Lucia
dc.contributor.authorBenediktsdóttir, Bryndís
dc.contributor.authorBertelsen, Randi Jacobsen
dc.contributor.authorBråbäck, Lennart
dc.contributor.authorDharmage, Shyamali
dc.contributor.authorFranklin, Karl A.
dc.contributor.authorGíslason, Þórarinn
dc.contributor.authorHolm, Mathias
dc.contributor.authorJanson, Christer
dc.contributor.authorJarvis, Deborah
dc.contributor.authorJõgi, Rain
dc.contributor.authorKim, Jeong-Lim
dc.contributor.authorKirkeleit, Jorunn
dc.contributor.authorLodge, Caroline
dc.contributor.authorMalinovschi, Andrei
dc.contributor.authorMartinez-Moratalla, Jesus
dc.contributor.authorNilsen, Roy Miodini
dc.contributor.authorPereira-Vega, Antonio
dc.contributor.authorGomez Real, Francisco
dc.contributor.authorSchlünssen, Vivi
dc.contributor.authorAccordini, Simone
dc.contributor.authorSvanes, Cecilie
dc.identifier.citationJohannessen, A., Lønnebotn, M., Calciano, L., Benediktsdóttir, B., Bertelsen, R. J., Bråbäck, L., . . . Svanes, C. (2019). Being overweight in childhood, puberty, or early adulthood: Changing asthma risk in the next generation? Journal of Allergy and Clinical Immunology.en_US
dc.description.abstractBackground Overweight status and asthma have increased during the last decades. Being overweight is a known risk factor for asthma, but it is not known whether it might also increase asthma risk in the next generation. Objective We aimed to examine whether parents being overweight in childhood, adolescence, or adulthood is associated with asthma in their offspring. Methods We included 6347 adult offspring (age, 18-52 years) investigated in the Respiratory Health in Northern Europe, Spain and Australia (RHINESSA) multigeneration study of 2044 fathers and 2549 mothers (age, 37-66 years) investigated in the European Community Respiratory Health Survey (ECRHS) study. Associations of parental overweight status at age 8 years, puberty, and age 30 years with offspring's childhood overweight status (potential mediator) and offspring's asthma with or without nasal allergies (outcomes) was analyzed by using 2-level logistic regression and 2-level multinomial logistic regression, respectively. Counterfactual-based mediation analysis was performed to establish whether observed associations were direct or indirect effects mediated through the offspring's own overweight status. Results We found statistically significant associations between both fathers' and mothers' childhood overweight status and offspring's childhood overweight status (odds ratio, 2.23 [95% CI, 1.45-3.42] and 2.45 [95% CI, 1.86-3.22], respectively). We also found a statistically significant effect of fathers' onset of being overweight in puberty on offspring's asthma without nasal allergies (relative risk ratio, 2.31 [95% CI, 1.23-4.33]). This effect was direct and not mediated through the offspring's own overweight status. No effect on offspring's asthma with nasal allergies was found. Conclusion Our findings suggest that metabolic factors long before conception can increase asthma risk and that male puberty is a time window of particular importance for offspring's health.en_US
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internasjonal*
dc.subjectAgeing Lungs in European Cohorts studyen_US
dc.subjectmultilevel mediation modelen_US
dc.subjectparental risk factorsen_US
dc.titleBeing overweight in childhood, puberty, or early adulthood: Changing asthma risk in the next generation?en_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.rights.holder© 2019 The Authorsen_US
dc.source.journalJournal of Allergy and Clinical Immunologyen_US
cristin.unitnameInstitutt for helse og funksjon

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Attribution-NonCommercial-NoDerivatives 4.0 Internasjonal
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