Show simple item record

dc.contributor.authorWathne, Jannicke Slettli
dc.contributor.authorKleppe, Lars Kåre Selland
dc.contributor.authorHarthug, Stig
dc.contributor.authorBlix, Hege Salvesen
dc.contributor.authorNilsen, Roy Miodini
dc.contributor.authorCharani, Esmita
dc.contributor.authorSmith, Ingrid
dc.coverage.spatialNorway, Western Norwaynb_NO
dc.identifier.citationWathne, J. S., Kleppe, L. K. S., Harthug, S., Blix, H. S., Nilsen, R. M., Charani, E., & Smith, I. (2018). The effect of antibiotic stewardship interventions with stakeholder involvement in hospital settings: a multicentre, cluster randomized controlled intervention study. Antimicrobial Resistance & Infection Control, 7(1), 1-12.nb_NO
dc.description.abstractBackground There is limited evidence from multicenter, randomized controlled studies to inform planning and implementation of antibiotic stewardship interventions in hospitals. Methods A cluster randomized, controlled, intervention study was performed in selected specialities (infectious diseases, pulmonary medicine and gastroenterology) at three emergency care hospitals in Western Norway. Interventions applied were audit with feedback and academic detailing. Implementation strategies included co-design of interventions with stakeholders in local intervention teams and prescribers setting local targets for change in antibiotic prescribing behaviour. Primary outcome measures were adherence to national guidelines, use of broad-spectrum antibiotics and change in locally defined targets of change in prescribing behaviour. Secondary outcome measures were length of stay, 30-day readmission, in-hospital- and 30-day mortality. Results One thousand eight hundred two patients receiving antibiotic treatment were included. Adherence to guidelines had an absolute increase from 60 to 66% for all intervention wards (p = 0.04). Effects differed across specialties and pulmonary intervention wards achieved a 14% absolute increase in adherence (p = 0.003), while no change was observed for other specialties. A pulmonary ward targeting increased use of penicillin G 2 mill IU × 4 for pneumonia and COPD exacerbations had an intended increase of 30% for this prescribing behaviour (p < 0.001). Conclusions Pulmonary wards had a higher increase in adherence, independent of applied intervention. The effect of antibiotic stewardship interventions is dependent on how and in which context they are implemented. Additional effects of interventions are seen when stakeholders discuss ward prescribing behaviour and agree on specific targets for changes in prescribing practice.nb_NO
dc.publisherBioMed Centralnb_NO
dc.rightsNavngivelse 4.0 Internasjonal*
dc.subjectantibiotic stewardshipnb_NO
dc.subjectaudit with feedbacknb_NO
dc.subjectacademic detailingnb_NO
dc.subjectgoal settingnb_NO
dc.titleThe effect of antibiotic stewardship interventions with stakeholder involvement in hospital settings: A multicentre, cluster randomized controlled intervention studynb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.rights.holder© The Author(s).nb_NO
dc.subject.nsiVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Infeksjonsmedisin: 776nb_NO
dc.source.journalAntimicrobial Resistance and Infection Controlnb_NO
cristin.unitnameInstitutt for sykepleiefag - Bergen

Files in this item


This item appears in the following Collection(s)

Show simple item record

Navngivelse 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Navngivelse 4.0 Internasjonal