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dc.contributor.authorBernhardsen, Guro Pauck
dc.contributor.authorStensrud, Trine
dc.contributor.authorHansen, Bjørge Hermann
dc.contributor.authorSteene-Johannessen, Jostein
dc.contributor.authorKolle, Elin
dc.contributor.authorNystad, Wenche
dc.contributor.authorAnderssen, Sigmund Alfred
dc.contributor.authorHallal, Pedro C.
dc.contributor.authorJanz, Kathleen F.
dc.contributor.authorKriemler, Susi
dc.contributor.authorAndersen, Lars Bo
dc.contributor.authorNorthstone, Kate
dc.contributor.authorResaland, Geir Kåre
dc.contributor.authorSardinha, Luís B.
dc.contributor.authorvan Sluijs, Esther M.F.
dc.contributor.authorRied-Larsen, Mathias
dc.contributor.authorEkelund, Ulf
dc.date.accessioned2020-12-22T09:05:45Z
dc.date.available2020-12-22T09:05:45Z
dc.date.created2020-11-16T12:16:21Z
dc.date.issued2020
dc.identifier.citationBernhardsen, G. P., Stensrud, T., Hansen, B. H., Steene-Johannesen, J., Kolle, E., Nystad, W., Anderssen, S. A., Hallal, P. C., Janz, K. F., Kriemler, S., Andersen, L. B., Northstone, K., Resaland, G. K., Sardinha, L. B., van Sluijs, E. M. F., Ried-Larsen, M., & Ekelund, U. (2020). Birth weight, cardiometabolic risk factors and effect modification of physical activity in children and adolescents: pooled data from 12 international studies. International Journal of Obesity, 44(10), 2052-2063.en_US
dc.identifier.issn0307-0565
dc.identifier.urihttps://hdl.handle.net/11250/2720703
dc.description.abstractObjectives Low and high birth weight is associated with higher levels of cardiometabolic risk factors and adiposity in children and adolescents, and increases the risk of cardiovascular diseases, obesity, and early mortality later in life. Moderate-to-vigorous physical activity (MVPA) is associated with lower cardiometabolic risk factors and may mitigate the detrimental consequences of high or low birth weight. Thus, we examined whether MVPA modified the associations between birth weight and cardiometabolic risk factors in children and adolescents. Methods We used pooled individual data from 12 cohort- or cross-sectional studies including 9,100 children and adolescents. Birth weight was measured at birth or maternally reported retrospectively. Device-measured physical activity (PA) and cardiometabolic risk factors were measured in childhood or adolescence. We tested for associations between birth weight, MVPA, and cardiometabolic risk factors using multilevel linear regression, including study as a random factor. We tested for interaction between birth weight and MVPA by introducing the interaction term in the models (birth weight x MVPA). Results Most of the associations between birth weight (kg) and cardiometabolic risk factors were not modified by MVPA (min/day), except between birth weight and waist circumference (cm) in children (p = 0.005) and HDL-cholesterol (mmol/l) in adolescents (p = 0.040). Sensitivity analyses suggested that some of the associations were modified by VPA, i.e., the associations between birth weight and diastolic blood pressure (mmHg) in children (p = 0.009) and LDL- cholesterol (mmol/l) (p = 0.009) and triglycerides (mmol/l) in adolescents (p = 0.028). Conclusion MVPA appears not to consistently modify the associations between low birth weight and cardiometabolic risk. In contrast, MVPA may mitigate the association between higher birth weight and higher waist circumference in children. MVPA is consistently associated with a lower cardiometabolic risk across the birth weight spectrum. Optimal prenatal growth and subsequent PA are both important in relation to cardiometabolic health in children and adolescents.en_US
dc.language.isoengen_US
dc.titleBirth weight, cardiometabolic risk factors and effect modification of physical activity in children and adolescents: pooled data from 12 international studiesen_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.description.versionpublishedVersionen_US
dc.rights.holder© The Author(s) 2020en_US
dc.source.pagenumber2052-2063en_US
dc.source.volume44en_US
dc.source.journalInternational Journal of Obesityen_US
dc.source.issue10en_US
dc.identifier.doi10.1038/s41366-020-0612-9
dc.identifier.cristin1848298
dc.relation.projectNorges forskningsråd: 249932/F20en_US
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode2


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