• Mental health and health related quality of life in mitochondrial POLG disease 

      Hikmat, Omar; Vederhus, Bente Johanne; Benestad, Merete Røineland; Engeset, Ida Malén E.; Klingenberg, Claus; Rasmussen, Magnhild; Tallaksen, Chantal; Brodtkorb, Eylert; Elgen, Irene Bircow; Bindoff, Laurence (Peer reviewed; Journal article, 2020)
      We aimed to assess the impact of POLG disease on mental health and quality of life in 15 patients using the Symptom Checklist-90-R (SCL-90-R) and Short-Form 36 Health Survey (RAND-36). We found increased scores in all nine ...
    • Upregulated PDK4 expression is a sensitive marker of increased fatty acid oxidation 

      Pettersen, Ina Katrine Nitschke; Tusubira, Deusdedit; Ashrafi, Hanan; Dyrstad, Sissel Elisabeth; Hansen, Lena; Liu, Xiao-Zheng; Hodneland, Linn I.; Løvsletten, Nils Gunnar; Berge, Kjetil; Wergedahl, Hege; Bjørndal, Bodil; Fluge, Øystein; Bruland, Ove; Rustan, Arild; Halberg, Nils; Røsland, Gro Vatne; Berge, Rolf Kristian; Tronstad, Karl Johan (Journal article; Peer reviewed, 2019)
      Fatty acid oxidation is a central fueling pathway for mitochondrial ATP production. Regulation occurs through multiple nutrient- and energy-sensitive molecular mechanisms. We explored if upregulated mRNA expression of the ...