Browsing HVL Open by Author "Kopperud, Reidun Kristin"

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    • Epac1 null mice have nephrogenic diabetes insipidus with deficient corticopapillary osmotic gradient and weaker collecting duct tight junctions 

      Åsrud, Kathrine Sivertsen; Bjørnstad, Ronja; Kopperud, Reidun Kristin; Pedersen, Line; van der Hoeven, Barbara; Karlsen, Tine Veronica; Rygh, Cecilie Brekke; Curry, Fitz-Roy; Bakke, Marit; Reed, Rolf K.; Tenstad, Olav; Døskeland, Stein Ove (Peer reviewed; Journal article, 2020)
      Aim The cAMP‐mediator Epac1 (RapGef3) has high renal expression. Preliminary observations revealed increased diuresis in Epac1−/− mice. We hypothesized that Epac1 could restrict diuresis by promoting transcellular collecting ...

    • Modulation of phospho-proteins by interferon-alpha and valproic acid in acute myeloid leukemia 

      Forthun, Rakel Brendsdal; Hellesøy, Monica; Sulen, Andre; Kopperud, Reidun Kristin; Sjøholt, Gry; Bruserud, Øystein; McCormack, Emmet; Gjertsen, Bjørn Tore (Journal article; Peer reviewed, 2019)
      Purpose Valproic acid (VPA) is suggested to be therapeutically beneficial in combination with interferon-alpha (IFNα) in various cancers. Therefore, we examined IFNα and VPA alone and in combinations in selected AML models, ...